Sentinel phenotype for rubella embryopathy: time-space distribution in Brazil.

Clinical use and control of the dispensing of thalidomide in Brasilia-Federal District, Brazil, from 2001 to 2012.

The use of thalidomide was never discontinued in Brazil where it is prescribed for leprosy type 2 reaction. Babies with birth defects compatible with the thalidomide embryopathy phenotype were born after 1965, an indication that control on drug dispensing and use failed in the country. The article reports data on thalidomide dispensing and clinical uses in the Federal District in 2011/12, when ...

Persistence of rubella antibody with and without embryopathy. A follow-up study of children exposed to maternal rubella.

Epidemiological Surveillance of Birth Defects Compatible with Thalidomide Embryopathy in Brazil

The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive survei...

Thymic hypoplasia due to congenital rubella.

Garcia, A. G. P., Olinto, F., and Fortes, T. G. 0. (1974). Archives of Disease in Childhood, 49, 181. Thymic hypoplasia due to congenital rubella. Two cases of rubella embryopathy are presented. In both, hypoplasia of the thymus and of the thymus-dependent lymphoid tissue was conspicuous. Vascular lesions identical with those described in the congenital rubella syndrome were present in the thym...

Congenital rubella syndrome surveillance as a platform for surveillance of other congenital infections, Peru, 2004-2007.

BACKGROUND Rubella during pregnancy can cause serious fetal abnormalities and death. Peru has had integrated measles/rubella surveillance since 2000 but did not implement congenital rubella syndrome (CRS) surveillance until 2004, in accordance with the Pan American Health Organization recommendations for rubella elimination. The article describes the experience from the CRS sentinel surveillanc...